I recettori intracellulari

I recettori intracellulari sono recettori per ligandi lipofili che penetrano passivamente nel citoplasma e/o nel nucleo per diffusione passiva. Essi sono proteine citoplasmatiche o nucleari che, in seguito all’interazione col proprio ligando, sono in grado di modulare la trascrizione genica. I recettori intracellulari rappresentano il bersaglio molecolare degli effetti degli ormoni steroidei e tiroidei, dei retinoidi e delle vitamine D ed A. Gli ormoni steroidei, ad esempio, grazie alla loro struttura idrofobica, attraversano la membrana cellulare e si legano a specifici recettori intracellulari. Quando avviene questo legame, la struttura ormone-recettore viaggia verso il nucleo dove si legherà a sequenze di DNA ben definite. Queste sequenze, prendono il nome di “elementi di risposta ormonale” (HRE) e sono situati a monte di un promotore genico. Il legame del recettore allo specifico HRE può avviare un processo attivo (regolazione positiva) o inibitorio (repressione) sull’espressione genica. Dunque, a seconda del processo si avrà o meno la trascrizione di geni specifici.

Sito di attivazione

Il meccanismo di attivazione dei recettori intracellulari, come già accennato, avviene nel citoplasma o nel nucleo a seconda della classe di ormoni considerata. Ad esempio, i recettori per alcuni ormoni corticosurrenalici, come l’aldosterone, in condizioni di riposo, sono localizzati nel citoplasma. Essi, arrivano al nucleo solo dopo la loro attivazione da parte del ligando. Altri recettori, invece, sono associati anche in condizioni di riposo a strutture nucleari. Di questi recettori, ricordiamo quelli per gli ormoni tiroidei, estrogeni, vitamina D e per l’acido retinoico. Ci sono poi alcuni recettori che sono inattivi nel citoplasma e che vengono attivati col distacco di alcune subunità inibitorie (proteine Hsp). Di questa tipologia sono i recettori per i glucocorticoidi e per il progesterone. Quando questo tipo di recettore viene attivato, arriva al nucleo in forma di dimero dove si lega ad una sequenza palindromica di DNA (Glucocorticoid Response Element, GRE). Questa sequenza è situata a monte di promotori per specifici geni di cui regolano l’attività sia in senso positivo che negativo.

 

Recettore intracellulare che lega un attivatore (ormone) e viaggia verso il nucleo dove permette l'alterazione della trascrizione genica. Fonte: Summa Gallicana
Recettore intracellulare che lega un attivatore (ormone) e viaggia verso il nucleo dove permette l’alterazione della trascrizione genica. Fonte: Summa Gallicana

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    Hello again!

    I have gotten an email saying that my original message was not delivered so here goes again. Please confirm receipt.

    As mentioned in my original message, I would like to contribute an article to your blog on how cryptocurrencies are reshaping the adult and more particularly the escort industry. I had a friend who ran an escort agency in the UK and he always had problems with the authorities, banks and even payment processors. I genuinely feel that cryptocurrencies have the potential to liberalise the escort industry and replace the anachronistic banking model which no longer works in today’s modern society.

    You can find the article on my G-Drive:

    https://drive.google.com/drive/folders/13pbNYoRoWLMHnrU1ySnxF6Zq7JMXsSI3?usp=sharing

    Whilst writing this article, I contacted a couple of websites to get some references and one website has even provided me with some images and have given their permission for you to use them. I have included a short bio about myself. I hope your audience enjoys reading my article.

    I can potentially write a couple more articles as and when I get some free time. It is crazy busy at work after all the festivities!

    Have a fab day!

    Regards
    Tony

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